منابع مشابه
Efficient Simulation of a Random Knockout Tournament
We consider the problem of using simulation to efficiently estimate the win probabilities for participants in a general random knockout tournament. Both of our proposed estimators, one based on the notion of “observed survivals” and the other based on conditional expectation and post-stratification, are highly effective in terms of variance reduction when compared to the raw simulation estimato...
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جنس alternaria یکی از فراوان ترین جنس های قارچی است که در مکان های متنوعی در سراسر دنیا یافت می شود و شامل گونه های بیماری زای گیاهی و پوده زی است که باعث وارد شدن خسارت به بسیاری از گیاهان و یا موجب فساد محصولات کشاورزی پس از برداشت می گردند. میزان خسارت در گونه های بیماریزای گیاهی متغیر است. تعدادی از گونه های این جنس بیماریزای گیاهان بوده و بیماریهای مهم و اقتصادی را در تعدادی ازگیاهان ایجاد...
15 صفحه اولA knockout may not always be a knockout.
To the Editor: In a recent issue of Circulation, Hoorntje et al1 presented data on a family with a duplication in exon 4 of HERG. A consanguineous marriage resulted in 2 homozygous offspring: one died before birth and the other had a severe cardiac phenotype characterized by arrhythmias and conduction defects. The importance of these findings regarding the role of HERG in the heart is clear. Th...
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Importance of herbal medicines have recently increased owing to rising interest in their health benefits. However, medicinal plant extracts are complex mixtures of phytochemicals that act synergistically or additively on specific and/or multiple molecular and cellular targets. Thus, it is difficult to examine the actual pharmacological roles of active compounds in plant extracts. This review de...
متن کاملKnockout Corner : Knockout mice for monoamine oxidase A
A line of transgenic mice was isolated in which transgene integration had caused a deletion in the gene encoding monoamine oxidase A, an enzyme that degrades serotonin and norepinephrine. This has provided an animal model of MAOA deficiency in humans, a condition characterized by borderline mental retardation and impulsive aggression. Received 13 June 1999 ; Reviewed 14 June 1999 ; Accepted 16 ...
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ژورنال
عنوان ژورنال: Nature Reviews Immunology
سال: 2003
ISSN: 1474-1733,1474-1741
DOI: 10.1038/nri1239